What is prontosil used for?
Prontosil, also called sulfamidochrysoidine, trade name of the first synthetic drug used in the treatment of general bacterial infections in humans. Prontosil was introduced into medicine in the 1930s.
What type of drug is prontosil?
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
Is the enzyme that converted prontosil to sulfanilamide?
Because p-aminobenznesulfonamide (sulfanilamide) (Fig. 1A), which can be generated upon the reductive cleavage of the azo bond of prontosil, was as effective as prontosil for controlling Streptococcal infections, prontosil was proposed to be reductively metabolized in the body into the active component sulfanilamide.
What are the mechanism of drug resistance?
The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. These mechanisms may be native to the microorganisms, or acquired from other microorganisms.
What kind of antibiotic is chloramphenicol?
Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa. It has also been used for the treatment of typhoid and cholera. Chloramphenicol is an antibiotic and is in the class of antimicrobials that inhibits protein synthesis.
Was Prontosil an antibiotic?
Prontosil was the first drug to successfully treat bacterial infections and the first of many sulfa drugs—forerunners of antibiotics. This achievement earned its creator a Nobel Prize, which the German authorities forced him to reject.
Why is it called penicillin V?
Names. There were four named penicillins at the time penicillin V was discovered (penicillins I, II, III, IV), however, Penicillin V was named “V” for Vertraulich (confidential); it was not named for the Roman numeral “5”. Penicillin VK is the potassium salt of penicillin V (K is the chemical symbol for potassium).