Can a male have 45 chromosomes?
Abstract. Maleness in association with the karyotype 45,X is a very rare and hitherto unexplained condition previously described in only four or five patients. This study was carried out to determine whether such males might actually possess Y-chromosomal material.
What is the phenotype of an individual who inherits 45 x?
Some patients with a 45,X/46,XY karyotype will have bilaterally descended testes and be phenotypic males, with even the presence of sperm. Therefore, the TS phenotype cannot predict the presence of a Y cell line.
What is chromosome 46 XY?
A 46, XY disorder of sex development (DSD) is a condition in which an individual with one X chromosome and one Y chromosome in each cell , the pattern normally found in males, have genitalia that is not clearly male or female.
What kind of chromosome does 45 x 46 XY have?
People with 45,X/46,XY have two different types of cell. One contains an X chromosome and a Y chromosome. The other contains a single X chromosome. A sizable number of people with 45,X/46,XY have a variant form where the Y chromosome has an unusual structure. See 45,X/ structurally abnormal Y chromosome [pages 13-15].
How is Turner syndrome related to 45, x / 46, XY karyotype?
We hypothesized that because 45,X/46,XY (X/XY) children share a cell line with Turner syndrome (TS), they also share co-morbidities described in TS. In addition, the presence of the Y chromosome in brain and in other body tissues would influence their function.
When to use 45, x / 46, XY?
When some cells only contain an X, the 45,X/46,XY condition arises. The condition has many different names. These include XY-Turners, mosaic XY/XO and XO/XY. Using the expression 45,X/46,XY is probably best, most nearly accurate, and the least confusing.
Is there a cure for 45, x / 46, XY?
When diagnosis of 45,X/46,XY is made postnatally, it is generally because of an abnormal phenotype; however, rare normal males have been identified. The most common presentation is TS, and both females and males with a 45,X/46,XY karyotype show poor growth and seem to benefit from GH treatment to achieve a normal growth pattern (144).
