What is pathophysiology of Nstemi?

What is pathophysiology of Nstemi?

Pathophysiology. ACS is simply a mismatch in the myocardial oxygen demand and myocardial oxygen consumption. While the cause of this mismatch in STEMI is nearly always coronary plaque rupture resulting in thrombosis formation occluding a coronary artery, there are several potential causes of this mismatch in NSTEMI.

What is pathophysiology of myocardial infarction?

In the clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary vessel caused by rupture of a vulnerable plaque. Ischemia induces profound metabolic and ionic perturbations in the affected myocardium and causes rapid depression of systolic function.

What three pathophysiological ways can a myocardial infarction develop?

Type 1: Spontaneous MI caused by ischemia due to a primary coronary event (eg, plaque rupture, erosion, or fissuring; coronary dissection) Type 2: Ischemia due to increased oxygen demand (eg, hypertension), or decreased supply (eg, coronary artery spasm or embolism, arrhythmia, hypotension)

What is Nstemi?

What is an NSTEMI? A Non-ST-Elevation Myocardial Infarction is a type of heart attack, often referred to as NSTEMI or a non-STEMI. In medical terminology, a heart attack is a myocardial infarction. An NSTEMI is a less severe form of heart attack than the STEMI because it inflicts less damage to the heart.

Why thrombolytics are contraindicated in NSTEMI?

In NSTEMI the blood flow is present but limited by stenosis. In NSTEMI, thrombolytics must be avoided as there is no clear benefit of their use. If the condition stays stable a cardiac stress test may be offered, and if needed subsequent revascularization will be carried out to restore a normal blood flow.

What is the pathophysiology of cardiac failure?

Pathophysiology of Heart Failure. In heart failure, the heart may not provide tissues with adequate blood for metabolic needs, and cardiac-related elevation of pulmonary or systemic venous pressures may result in organ congestion.

What is disease pathophysiology?

Pathophysiology: Deranged function in an individual or an organ due to a disease. For example, a pathophysiologic alteration is a change in function as distinguished from a structural defect.

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