What is the role of the HOXC8 gene?
HOXC8 serves as a transcription factor to regulate the expression of genes that are implicated in skeletal and neural development in embryogenesis and cancer progression.
Do reptiles have Hox genes?
A complete inventory of Hox genes in crocodiles, turtles, snakes, and lizards has been reported [Liang et al., 2011]. In this inventory, all Hox genes known in placental mammals and birds were present in reptiles, except for snakes.
Is I gene a constitutive gene?
The activity, i.e. transcription, of genes is highly regulated. Constitutive genes are those that are always active. Genes for ribosomes are an example. They are constantly being transcribed because ribosomes are constantly needed for protein synthesis.
Which of given is constitutive gene?
A constitutive gene is a gene that is transcribed continually as opposed to a facultative gene, which is only transcribed when needed. A housekeeping gene is a gene that is required to maintain basic cellular function and so is typically expressed in all cell types of an organism.
How many Hox genes are there?
39
The 39 human HOX genes are located in four clusters (A-D) on different chromosomes at 7p15, 17q21. 2, 12q13, and 2q31 respectively and are assumed to have arisen by duplication and divergence from a primordial homeobox gene.
When a gene is expressed is produced?
Gene expression is the process by which the instructions in our DNA are converted into a functional product, such as a protein. When the information stored in our DNA? is converted into instructions for making proteins? or other molecules, it is called gene expression?.
What would happen if a Hox gene mutated?
Similarly, mutations in the Hox genes can result in body parts and limbs in the wrong place along the body. Like a play director, the Hox genes do not act in the play or participate in limb formation themselves. The protein product of each Hox gene is a transcription factor.
What type of diseases can be linked to HOX genes?
HOX genes play a fundamental role in the development of the vertebrate central nervous system, axial skeleton, limbs, gut, urogenital tract and external genitalia, but it is only in the last 4 years that mutations in two of the 39 human HOX genes have been shown to cause congenital malformations; HOXD13, which is …
