What does 2/3 pentanedione do to the body?
In longer 2-week inhalation studies in rats, researchers from the National Institute of Environmental Health Sciences (NIEHS) found that repeated exposures to either 2,3-pentanedione or diacetyl can cause airway fibrosis, including obliterative bronchiolitis-like changes, in rats (Morgan et al. 2016 ).
Where does 2/3 pentanedione come from?
It derives from a hydride of a pentane.
Is Acetoin a Diketone?
There are several different types of diketones. The main chemicals in e-liquids that are known as diketones are diacetyl, acetyl propionyl and acetoin.
Is diacetyl a vape?
Diacetyl is also present in many e-cigarettes sold in the United States. The chemical is used in e-cigarettes for the same reason it is used in food: for flavoring. Diacetyl allows vaping companies to offer fruit, candy, and dessert flavors — flavors especially appealing to young people. Diacetyl is safe to ingest.
Is Acetoin safe to vape?
Acetoin use in e-liquids is an inevitable source of diacetyl exposure for e-cigarette users. Acetoin, acetyl propionyl and diacetyl are avoidable hazards for vapers, and we recommend e-liquid manufacturers move away from their use in e-liquid formulations.
How is 2, 3 pentanedione released to the environment?
EXPOSURE: Workers that use 2,3-pentanedione may breathe in mists or have direct skin contact. The general population may be exposed by breathing in food vapors and consumption of food. Exposure may also occur from smoking cigarettes. If 2,3-pentanedione is released to the environment, it will be broken down in air.
What are the guidelines for occupational exposure to 2, 3 pentanedione?
The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (NIOSH, CDC) is continuing the peer review process of the draft document entitled, Criteria for a Recommended Standard: Occupational Exposure to Diacetyl and 2,3-pentanedione.
Are there any new data on diacetyl and 2, 3-pentanedione?
Overview of changes: After the previous peer review and public comment process was initiated, the National Toxicology Program released a new dataset on diacetyl and 2,3-pentanedione. Chapter 6, titled Quantitative Risk Assessment Based on Animal Data, has been updated to accommodate this new dataset.
What kind of liquid is 2, 3 pentanedione?
IDENTIFICATION AND USE: 2,3-Pentanedione is a yellow liquid. It is used as flavoring agent (butter flavoring) including many e-cigarette brands. HUMAN EXPOSURE AND TOXICITY: Inhalation of butter flavoring by workers in the microwave popcorn industry may result in “popcorn workers’ lung.”.
