What does high soluble transferrin receptor mean?
The level of soluble transferrin receptor (sTfR) will be increased with iron deficiency. If you have anemia and your sTfR level is elevated, then it is likely that you have iron deficiency anemia.
What is a normal soluble transferrin receptor?
Normal adult levels vary from 2 to 5 mg/l. However, pediatric studies are few and describe normal ranges to the tune of 1.0–3.0 mg/l, which are relatively lower than that of adults. In present study 40 healthy children (2–12 years) were evaluated to establish normal soluble transferrin receptor range.
What information does serum transferrin receptor provide?
The serum receptor provides a quantitative measure of functional iron deficiency and distinguishes the associated anemia from that of chronic disease.
How do you interpret transferrin saturation?
Transferrin saturations of less than 20% indicate iron deficiency, while transferrin saturations of more than 50% suggest iron overload. The terms transferrin saturation and iron-binding capacity, saturation, are interchangeable; however, this value is now most commonly referred to simply as transferrin saturation.
What happens if transferrin saturation is low?
The normal range for transferrin is 204 to 360 mg/dl. If you have a higher amount, you may have iron-deficiency anemia. If you have a lower level, you may have another problem, such as liver disease and hemolytic anemia. Transferrin may also be measured using a value called total iron-binding capacity (TIBC).
Is ferritin and transferrin the same thing?
Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin. The ferritin then binds to another substance called transferrin. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.
Is ferritin the same as transferrin?
What does serum transferrin measure?
The transferrin, total iron-binding capacity (TIBC) or unsaturated iron-binding capacity (UIBC) test may be used along with other iron tests to assess the amount of iron circulating in the blood, the total capacity of the blood to transport iron, and the amount of stored iron in the body.
What is the difference between transferrin and ferritin?
Although ferritin is an indicator of cellular iron stores in healthy subjects, it provides little information on iron turnover in the body. Transferrin is a “shuttle protein” (24), mainly synthesized in the liver, and its principal role is to transport ionic iron to the liver, spleen, and bone marrow (25).
What causes low transferrin?
Low transferrin can be due to poor production of transferrin by the liver (where it’s made) or excessive loss of transferrin through the kidneys into the urine. Many conditions including infection and malignancy can depress transferrin levels. The transferrin is abnormally high in iron deficiency anemia.
How is the concentration of soluble transferrin receptor measured?
Soluble transferrin receptor arises from proteolysis of the intact protein on the cell surface, leading to monomers that can be measured in plasma and serum. Thus, the concentration of sTfR in plasma or serum is an indirect measure of total TfR.
How is soluble transferrin receptor ( sTfR ) related to iron?
If an interpretive report is provided, the reference value field will state this. It is reported that African Americans may have slightly higher values. Soluble transferrin receptor (sTfR) concentrations are inversely related to iron status; sTfR elevates in response to iron deficiency and decreases in response to iron repletion.
How is transferrin receptor released from the plasma membrane?
Plasma membrane-bound transferrin receptor is released by proteolytic cleavage of the extracellular domain, resulting in the formation of a truncated soluble transferrin receptor (sTfR) that circulates freely in the blood. The concentration of sTfR is an indicator of iron status.
What does low transferrin receptor ( SF ) stand for?
Low SF is diagnostic for storage iron depletion and iron deficiency. However, SF is also increased during infection and inflammation, as well as liver disease, which can cloud its interpretation.