What are RBC Alloantibodies?

What are RBC Alloantibodies?

In blood banking, an antibody formed in response to pregnancy, transfusion, or transplantation targeted against a blood group antigen that is not present on the person’s red blood cells.

What is the meaning of autoantibody?

(AW-toh-AN-tee-BAH-dee) An antibody made against substances formed by a person’s own body. Autoantibodies can directly destroy cells that have the substances on them or can make it easier for other white blood cells to destroy them.

What is RBC positive?

When an RBC antibody screen is used to screen prior to a blood transfusion, a positive test indicates the need for an antibody identification test to identify the antibodies that are present.

What is RBC in blood test?

A red blood cell (RBC) count is a blood test that tells you how many red blood cells you have. Red blood cells contain a substance called haemoglobin, which transports oxygen around the body.

What is a DAT blood test?

The direct antiglobulin test (DAT) determines whether your red blood cells (RBCs) circulating in the bloodstream are covered with antibodies. The antibodies that are attached to the surface of the RBCs are responsible for their destruction.

What is RBC in blood test normal range?

A normal RBC count would be: men – 4.7 to 6.1 million cells per microlitre (cells/mcL) women – 4.2 to 5.4 million cells/mcL.

What is the medical definition of alloantibody?

Medical Definition of alloantibody. : an antibody produced following introduction of an alloantigen into the system of an individual of a species lacking that particular antigen. — called also isoantibody.

What are the factors that contribute to the formation of alloantibody?

Frecuency of red blood cell alloantibody in Kuwaiti population. (7) Other alloantibody formation factors include sex, number and timing of blood transfusions, age, pregnancy, recipient’s diagnosis and treatment, and genetic factors related to the antigenic response.

What makes an IgG alloantibody an autoantibody?

In most cases, an IgG alloantibody or autoantibody arises in response to the drug or a drug-platelet protein complex. Recently transfused cells may not have all antigens fully saturated with antibody, and additional absorption of alloantibody might take place with prolonged storage.

What is the destructive power of alloantibodies?

The destructive power of alloantibodies of the recipients directed against HLA class I and II molecules varies [112], depending on the level of antibody [33], immunoglobulin isotype, target antigen, and the type of organ transplanted [117, 118].

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