What does interleukin 7 receptor do?
In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.
Which cells express IL7R?
The IL7R is expressed on naïve T cells and is downregulated following TCR engagement (8, 9, 13-21). T cells then have the capacity to upregulate the IL7R for their continued maintenance (22-24).
Which cell expresses IL 7r?
Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein.
What is the interleukin7 receptor gene?
IL7R (Interleukin 7 Receptor) is a Protein Coding gene. Diseases associated with IL7R include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Multiple Sclerosis 3. Among its related pathways are Jak-Stat Signaling Pathway (sino) and PEDF Induced Signaling.
What is CD127 a marker for?
CD127 is a useful marker for identifying memory and effector T cells. Its expression is down-modulated on Treg cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
What produces IL-7?
IL-7 is mainly produced by non-hematopoietic cells including keratinocytes in the skin, fibroblastic stromal cells in the bone marrow [7] and lymphoid organs [8,9], epithelial cells in the thymus [7], prostatic epithelium [10] and the intestine. Immune cells, such as dendritic cells (DCs) can also produce IL-7 [11].
What is the function of the IL7R gene?
The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells.
Where are IL-7 receptors found in the body?
These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells.
Why is IL-7 important to the immune system?
IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells.
How does IL7 receptor signaling lead to negative regulatory feedback?
For example, IL7 receptor signaling down-regulates expression of its own receptor, so that IL7 signaling leads to suppression of further IL7R signaling. Initiating negative regulatory feedback is quite unusual because expression of other members of the γc receptor family is up-regulated by their cognate cytokine signals.
