Which drugs cause neuroleptic malignant syndrome?
The primary trigger of NMS is dopamine receptor blockade and the standard causative agent is an antipsychotic. Potent typical neuroleptics such as haloperidol, fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine have been most frequently associated with NMS and thought to confer the greatest risk.
Do typical antipsychotics cause neuroleptic malignant syndrome?
All classes of antipsychotics have been associated with neuroleptic malignant syndrome, including low-potency neuroleptics, high-potency neuroleptics, and the newer (or atypical) antipsychotics. Neuroleptic malignant syndrome has been reported most frequently in patients taking haloperidol and chlorpromazine.
Why is neuroleptic malignant life threatening?
NMS can damage muscles and cause very high or low blood pressure. If you’re not treated, you can get serious problems, like: Kidney failure. Heart and lung failure.
Why is NMS a medical emergency?
Neuroleptic malignant syndrome (NMS) is a lethal medical emergency associated with the use of neuroleptic agents and antiemetics that is characterized by a typical clinical syndrome of hyperthermia, rigidity, mental status alteration, and dysautonomia.
What medicine causes tardive dyskinesia?
Medicines that most commonly cause this disorder are older antipsychotics, including:
- Chlorpromazine.
- Fluphenazine.
- Haloperidol.
- Perphenazine.
- Prochlorperazine.
- Thioridazine.
- Trifluoperazine.
Is there such a thing as neuroleptic malignant syndrome?
Neuroleptic malignant syndrome. Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that can occur in response to neuroleptic or antipsychotic medication.
What makes neuroleptic malignant syndrome catatonia-like?
Neuroleptic malignant syndrome Neuroleptic malignant syndrome is a catatonia-like reaction that can be caused by antipsychotic drugs [26R]. There have been reports of patients who developed the syndrome while taking a combination of risperidone and lithium [27A].
Is there a risk of anesthesia for neuroleptic malignant syndrome?
Anesthesia may be a risk to individuals who have experienced neuroleptic malignant syndrome. Early identification of and treatment for individuals with neuroleptic malignant syndrome improves outcome.
How is neuroleptic malignant syndrome related to rhabdomyolysis?
Neuroleptic malignant syndrome is a rare, but life-threatening, disorder characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction.62 Creatine kinase may be elevated due to the muscle rigidity and may lead to rhabdomyolysis.
