What is the medication linagliptin used for?
Linagliptin is a medicine used to treat type 2 diabetes. Type 2 diabetes is an illness where the body does not make enough insulin, or the insulin that it makes does not work properly. This can cause high blood sugar levels (hyperglycaemia).
What kind of medication is linagliptin?
Linagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high.
Is linagliptin better than metformin?
In terms of treatment convenience, our data showed that linagliptin was superior to metformin.
What is the side effect of linagliptin?
Common side effects may include: runny or stuffy nose, sore throat; cough; or. diarrhea….
| Number (%) of Patients | ||
|---|---|---|
| Nasopharyngitis | 254 (7.0) | 132 (6.1) |
| Diarrhea | 119 (3.3) | 65 (3.0) |
| Cough | 76 (2.1) | 30 (1.4) |
Can I take metformin and linagliptin together?
Linagliptin works by regulating the levels of insulin your body produces after eating. Linagliptin and metformin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.
Does tradjenta make you gain weight?
In a clinical trial, it was shown that Tradjenta (linagliptin) used together with metformin, controls type 2 diabetes with less hypoglycemia (low blood sugar) or weight gain than Amaryl (glimepiride) when used as a second-choice treatment. Weight gain is not a common side effect when using this medication.
What is the best time to take Tradjenta?
Weight gain is not a common side effect when using this medication. What time of day should you take Tradjenta (linagliptin)? You can generally take the tablet at any time of day that’s convenient for you, but it is best to take Tradjenta (linagliptin) at the same time each day.
How safe is linagliptin?
Throughout the study, linagliptin was well tolerated, with a safety and tolerability profile similar to placebo in this vulnerable patient population. In particular, linagliptin was associated with very low risk of severe hypoglycemia, stable body weight, and no cases of drug-related renal failure.
How does sitagliptin work in the pancreas?
By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the α-cells of the pancreas. This drives blood glucose levels toward normal. The effects of sitagliptin have been ascribed primarily to effects on islet cell function.
What is the effect of sitagliptin on HBA 1C?
After 12 weeks of treatment, all doses of sitagliptin resulted in a strong reduction in HbA 1c levels ranging from 0.38% to 0.77% with 50-mg twice daily producing the greatest effect. The effect of sitagliptin on body weight was neutral and with very low incidence of hypoglycemia.
How to report side effects of sitagliptin to the FDA?
You may report side effects to FDA at 1-800-FDA-1088. -When used in combination with an insulin secretagogue (e.g. sulfonylurea) or insulin, a lower dose of the insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia.
What is the bioavailability of 100 mg sitagliptin?
Sitagliptin is well absorbed and its oral bioavailability is 87%. The maximum plasma concentration after intake of 100 mg sitagliptin is reached after 1 to 4 h. Binding to plasma proteins is low (38%) and the Vd is 1981.
