How do you get hemophilia B?

How do you get hemophilia B?

Hemophilia B is caused by mutations in the F9 gene. The F9 gene is located on the X chromosome and thus is inherited as an X-linked recessive trait. In about 30% of new cases of hemophilia B, the altered gene occurs spontaneously without a previous family history.

Why is hemophilia B called Christmas?

Hemophilia B is the second most common type of hemophilia. It is also known as factor IX deficiency, or Christmas disease. It was originally named “Christmas disease” after the first person diagnosed with the disorder back in 1952.

What is hemophilia B Christmas?

Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.

What is the difference between hemophilia A and hemophilia B?

Haemophilia can be defined as a bleeding disorder that is caused by the deficiency of the clotting factors. The differences between Haemophilia A and B are in the low level – Haemophilia A means low levels of factor (8) and Haemophilia B is low levels of factor (9).

Is there a cure for hemophilia B?

There is currently no cure for hemophilia. Effective treatments do exist, but they are expensive and involve lifelong injections several times per week to prevent bleeding.

Why haemophilia is called Royal disease?

Hemophilia is sometimes referred to as “the royal disease,” because it affected the royal families of England, Germany, Russia and Spain in the 19th and 20th centuries. Queen Victoria of England, who ruled from 1837-1901, is believed to have been the carrier of hemophilia B, or factor IX deficiency.

What is the life expectancy of someone with hemophilia?

During this period, it exceeded mortality in the general population by a factor of 2.69 (95% confidence interval [CI]: 2.37-3.05), and median life expectancy in severe hemophilia was 63 years.

What is the difference between hemophilia an and B?

Difference Between Hemophilia A and B Hemophilia B is less common than Hemophilia A. When consider the general population, Hemophilia B affects approximately one in 50,000 people while, Hemophilia A affects fewer than one in 10,000 people. Hemophilia A occurs due to the deficiency of factor VIII, whereas Hemophilia B occurs due to the deficiency of factor IX.

What medications are used to treat hemophilia?

Antifibrinolytics are drugs that help prevent the breakdown of clots formed during a bleeding episode. They are often used to treat more mild forms of hemophilia A . Examples include aminocaproic acid (Amicar) and tranexamic acid (Lysteda).

What is the prognosis for hemophilia?

Life expectancy in hemophilia varies, depending on whether patients receive appropriate treatment. Many patients still die before adulthood due to inadequate treatment. With proper treatment, life expectancy is only about 10 years less than healthy men.

What is the current treatment for hemophilia?

The current, most-used treatment for hemophilia A is factor replacement therapy. This is done by infusing (giving medication into a vein) a FVIII product into the affected person.

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