What are the symptoms of GPS?
Symptoms
- Prickling, pins and needles sensations in your fingers, toes, ankles or wrists.
- Weakness in your legs that spreads to your upper body.
- Unsteady walking or inability to walk or climb stairs.
- Difficulty with facial movements, including speaking, chewing or swallowing.
- Double vision or inability to move eyes.
How is gray platelet syndrome diagnosed?
The diagnosis of GPS requires demonstration of the absence or marked reduction of α-granules in platelets observed by electron microscopy (EM). Megakaryocytes also show decreased α-granules. Platelet dense bodies and lysosomes are unaffected.
What causes GPS disease?
GPS results from the absence or reduction of alpha-granules in platelets, which store proteins that promote platelet adhesiveness and wound healing when secreted during an injury. GPS is caused by mutations in the NBEAL2 gene and inherited in an autosomal recessive manner.
What virus attacks the nervous system?
Viruses that infect the central nervous system (brain and spinal cord) include herpesviruses (see also herpes simplex virus infections), arboviruses, coxsackieviruses, echoviruses, and enteroviruses.
Can you pass GBS to your partner?
Like many bacteria, GBS may be passed from one person to another through skin-to-skin contact, for example, hand contact, kissing, close physical contact, etc. As GBS is often found in the vagina and rectum of colonised women, it can be passed through sexual contact.
What causes the gray platelet syndrome?
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis.
What autoimmune disease affects the nerves?
Guillain-Barré syndrome, sometimes known as GBS, is a rare but serious autoimmune disorder in which the immune system attacks healthy nerve cells in the peripheral nervous system (PNS). This leads to weakness, numbness, and tingling.
What viruses cause neurological problems?
Many viruses causing neurological disorders belong to the family of Adenoviridae, Arboviruses (arthropod-borne-virus), Arenaviridae, Herpesviridae, Picornaviridae, Paramyxoviridae as well as Togaviridae.
How many people have been diagnosed with GPS?
About 60 cases from various populations around the world have been described in the literature to date. GPS results from the absence or reduction of alpha-granules in platelets, which store proteins that promote platelet adhesiveness and wound healing when secreted during an injury.
What does GPS stand for in medical terms?
Gray platelet syndrome. Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis. GPS is…
What causes Gray platelet syndrome ( GPS ) in humans?
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis. GPS is…
What are the signs and symptoms of GPS?
Signs of GPS typically arise at birth or in childhood, these signs and symptoms include thrombocytopenia, bruising susceptibility, and epistaxis. Typically, the observed low platelet count in individuals is progressive, this can result in fatal hemorrhages later in life.
