Is 2 Arachidonoyl glycerol an enzyme?
2-Arachidonoylglycerol (2-AG) is the most abundant endocannabinoid and plays a major role in CNS development and synaptic plasticity. These enzymes can either degrade 2-AG into its components, arachidonic acid and glycerol, or transform 2-AG into highly bioactive signal molecules.
What does2 arachidonoylglycerol do?
2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor.
Is 2-AG a neuropeptide?
2-AG, unlike anandamide (another endocannabinoid), is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in mouse and rat brain (~5-10 nmol/g tissue).
Where does 2-arachidonoylglycerol come from in the body?
2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid receptors. 2-AG is rapidly formed from arachidonic acid -containing phospholipids through increased phospholipid metabolism,…
What is the effect of 2-arachidonoylglycerol on cerebellar membranes?
“Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB (1) receptor-dependent G-protein activation in rat cerebellar membranes”. British Journal of Pharmacology. 134 (3): 664–72. doi: 10.1038/sj.bjp.0704297.
Which is the inhibition of 2-arachidonylglycerol ( 2-AG ) biosynthesis?
Valdeolivas et al (2013) The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Br J Pharmacol 4 e862 PMID: 24136226
How is 2-AG synthesized from diacylglycerol lipase?
The activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL) mediate its formation. 2-AG is synthesized from arachidonic acid -containing diacylglycerol (DAG) .