What are signs of theophylline toxicity?

Consequences of theophylline intoxication include metabolic disturbances (hypokalemia, hyperglycemia, and metabolic acidosis), nausea, vomiting, and, in severe cases, seizures, cardiac arrhythmias, and death.

Can theophylline cause junctional tachycardia?

It can be associated with digitalis toxicity. It may also be due to onset of acute coronary syndrome, heart failure, conduction system diseases with enhanced automaticity, or administration of theophylline.

Can theophylline cause heart arrhythmia?

Conclusion: Theophylline causes tachycardia and serious arrhythmias even at STC considered to be therapeutic. Multifocal atrial tachycardia, an arrhythmia associated with use of this drug, may herald sudden cardiac death.

What can causes theophylline toxicity?

Therefore, Theophylline toxicity occurs when serum theophylline levels surpass the levels in the therapeutic range. This can occur by intentional overdose or unintentionally when metabolism and/or clearance of theophylline is altered due to certain physiological stressors.

What are the contraindications of theophylline?

Who should not take THEOPHYLLINE?

overactive thyroid gland.
a condition with low thyroid hormone levels.
diabetes.
cystic fibrosis.
alcoholism.
high blood pressure.
a heart attack.
angina, a type of chest pain.

Can theophylline cause AFIB?

In conclusion, atrial fibrillation can be triggered by some drugs as theophylline, for selected patients, “pill in the pocket administration”is fesaible and reduces hospital admissions and emergency department visits [7].

What is the toxic level of theophylline?

Toxic levels are considered to be higher than 20 mcg/mL; however, adverse effects may be evident within the normal therapeutic range. Severe complications including cardiac dysrhythmias, seizures, and death can be observed with levels of 80-100 mcg/mL.

What is the indication of theophylline?

Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.

What is normal theophylline level?

The therapeutic concentration for theophylline, when used as a bronchodilator to treat asthma, is generally considered to be 5–15 mcg/mL (28-83 micromol/L) for adults, 5–10 mcg/mL (28–55 micromol/L) for children and neonates. Levels greater than 20 mcg/mL (111 micromol/L) are considered toxic.