What are the three functions of the invariant chain?
Invariant chain does not merely function as an MHC class II chaperone preventing peptide loading in the ER, stimulating exit from the ER, and modulating antigenic peptide loading, but it may have additional functions as well.
What is the role of the invariant chain II )?
Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.
What does the invariant chain do?
The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74.
What is the role of the invariant chain II )? Quizlet?
What is the function of the invariant chain in the loading of antigen onto MHC Class II molecules? The invariant chain blocks the antigen binding region of the MHC Class II molecule while its in the ER to prevent cell peptides from prematurely binding it before it reaches the phagolysosome.
What kind of protein is the invariant chain?
Invariant chain is a nonpolymorphic, non–MHC-encoded type II membrane glycoprotein protein that associates with class II during biosynthesis.
Which is the cell surface form of the invariant chain?
The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74.
How is invariant chain related to histocompatible gene complex?
The assembly and intracellular transport of class II proteins is mediated by a chaperone protein, the invariant chain. Despite its chromosomal location outside the major histocompatibility gene complex, the invariant chain shares some promoter elements with class II proteins.
What is the function of the invariant chain in the RER?
The nascent MHC class II protein in the rough endoplasmic reticulum (RER) binds a segment of the invariant chain (Ii; a trimer) in order to shape the peptide-binding groove and prevent the formation of a closed conformation. The invariant chain also facilitates the export of MHC class II from the RER in a vesicle.
