What is difference between azithromycin and erythromycin?
Conclusions: Azithromycin stimulates antral activity similar to erythromycin and moreover has a longer duration of effect. However, unlike erythromycin, azithromycin does not have significant drug-drug interactions and maybe a potential new medication for the treatment of gastroparesis and gastrointestinal dysmotility.
What are macrolide antibiotics used for?
Macrolides are a class of antibiotic that includes erythromycin, roxithromycin, azithromycin and clarithromycin. They are useful in treating respiratory, skin, soft tissue, sexually transmitted, H. pylori and atypical mycobacterial infections.
How much is the molecular weight of azithromycin?
Azithromycin PubChem CID 447043 Synonyms azithromycin Zithromax 83905-01-5 Sumame Molecular Weight 749.0 Date s Modify 2021-05-15 Create 2005-06-24
How is azithromycin related to serum aminotransferases?
Like other macrolide antibiotics, azithromycin has been linked to a low rate of acute, transient and asymptomatic elevation in serum aminotransferases which occurs in 1% to 2% of patients treated for short periods, and a somewhat higher proportion of patients given azithromycin long term.
Are there any gram resistant strains of azithromycin?
NOTE: Azithromycin demonstrates cross-resistance with erythromycin-resistant gram-positive strains. Most strains of Enterococcus faecalis and methicillin-resistant staphylococci are resistant to azithromycin. Beta-lactamase production should have no effect on azithromycin activity.
How does azithromycin bind to the 50S ribosome?
Upon oral administration, azithromycin reversibly binds to the 23S rRNA of the 50S ribosomal subunit of the bacterial ribosome of susceptible microorganisms, thereby inhibiting the translocation step of protein synthesis by preventing the assembly of the 50S ribosomal subunit.