Do dendritic cells have MHC class I and II?
MHC I are found on all nucleated body cells, and MHC II are found on macrophages, dendritic cells, and B cells (along with MHC I).
Do dendritic cells have MHC class I?
All professional APCs also express MHC class I molecules as well. The main types of professional antigen-presenting cells are dendritic cells, macrophages and B cells.
What is follicular dendritic cells?
Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.
What is the difference between MHC class 1 and 2?
The main difference between MHC class 1 and 2 is that MHC class 1 molecules present antigens to cytotoxic T cells with CD8+ receptors whereas MHC class 2 molecules present antigens to helper T cells with CD4+ receptors.
What is the function of follicular dendritic cells?
Follicular dendritic cells (FDCs) are stromal cells residing in primary follicles and in germinal centers of secondary and tertiary lymphoid organs (SLOs and TLOs). There, they play a crucial role in B-cell activation and affinity maturation of antibodies.
What is MHC and its function?
The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. The MHC complex on the cell surface is necessary for cell self-recognition and the prevention of the immune system targeting its own cells.
What is the main difference between MHC class 1 and 2?
What kind of antigen does follicular dendritic cell express?
Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells.
How are follicular dendritic cells different from DCS?
These cells were first described in 1965 and, although they have a very dendritic morphology, are not dendritic cells (DCs). Unlike DCs, FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.
Where are FDCs located in the bone marrow?
FDCs are an important subset of stromal cells that are located within the B cell follicles and germinal centers of SLO and are distinct from the bone marrow-derived classical dendritic cells (DCs) ( Shortman and Liu, 2002 ).
How are follicular dendritic cells selected as future memory cells?
Follicular DCs receptors CR1, CR2 and FcγRIIb trap antigen opsonized by complement or antibodies. These antigens are then taken up in a non-degradative cycling endosomal compartment for later presentation to B cells. To become selected as a future memory cell, GC B cells must bind the antigen presented on FDCs, otherwise they enter apoptosis.
